Controlling transcription of coding and non-coding RNAs

Dr. Karen Adelman is the Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. She is also a Member of the Gene Regulation Observatory at the Broad Institute, and the Ludwig Cancer Center at Harvard Medical School. The Adelman lab pioneered genomic studies of RNA polymerase II (RNAPII) transcription, revealing that pausing of RNAPII in early elongation is a central regulatory step in metazoan gene expression. Ongoing work probes the interplay between transcription, RNA processing and epigenetic machineries to elucidate the determinants of mature mRNA formation in health and disease.